Showing information for HMDB0002712 ('1,5-anhydroglucitol', '1,5-anhydrosorbitol')

Metabolite information
HMDB ID HMDB0002712
Synonyms
1,5-AG
1,5-Anhydroglucitol
1,5-anhydro-D-Glucitol
1,5-anhydro-D-Sorbitol
1-Deoxyglucose
Adult-onset diabetes
Csf
Cytoplasma
Niddm
Non-insulin-dependent diabetes mellitus
Prostate gland
Chemical formula C6H12O5
IUPAC name
(2R,3S,4R,5S)-2-(hydroxymethyl)oxane-3,4,5-triol
CAS registry number 154-58-5
Monisotopic molecular weight 164.068473494

Chemical taxonomy
Super class Organic oxygen compounds
Class Organooxygen compounds
Sub class Carbohydrates and carbohydrate conjugates

Biological properties
Pahtways
Author-emphasized biomarker in the paper(s)

Lung cancer metabolomics studies that identify HMDB0002712 ('1,5-anhydroglucitol', '1,5-anhydrosorbitol')

Reference Country Specimen Marker function Participants (Case) Participants (Control)
Cancer type Stage Number Gender (M,F) Age mean (range) (M/F) Smoking status Type Number Gender (M,F) Age mean (range) (M/F) Smoking status
Roś-Mazurczyk et al. 2017 – serum diagnosis adenocarcinoma, squamous cell carcinoma I, II, III 31 17, 14 52-72 – healthy 92 52, 40 52-73 –
Fahrmann et al. 2015 – plasma diagnosis adenocarcinoma I, II, III, IV 52 17, 35 65.9 ± 9.66 – healthy 31 11, 20 64.1 ± 8.97 –
Fahrmann et al. 2015 – serum diagnosis adenocarcinoma I, II, III, IV 49 17, 32 65.9 ± 9.87 – healthy 31 11, 20 64.1 ± 8.97 –
Miyamoto et al. 2015 – blood diagnosis NSCLC, SCLC, mesothelioma, secondary metastasis to lung I, II, III, IV 11 4, 7 67 (61-73) / 67 (47-76) smoker, non-smoker healthy 11 5, 6 69 (61-83) / 54 (44-61) unknown
Miyamoto et al. 2015 – blood diagnosis adenocarcinoma unknown (mostly late stage) 18 10, 8 67 (50-85) / 62 (53-72) former, current healthy 20 8, 12 64 (49-80) / 66 (58-82) former, current
Moreno et al. 2018 – tissue therapy, diagnosis adenocarcinoma I, II, III 33 24, 9 62.11 ± 9.73 – tumor vs. adjacent normal tissue 33 24, 9 62.11 ± 9.73 –
Mazzone et al. 2016 – serum – adenocarcinoma, squamous cell carcinoma I, II, III 94 55.3%, 44.7% 68.7 – at-risk controls 190 50.5%, 49.5% 66.2 –
Fahrmann et al. 2015 – serum diagnosis adenocarcinoma I, II, III, IV 43 21, 22 67.3 ± 10.10 – healthy 43 21, 22 65.9 ± 8.05 –
Moreno et al. 2018 – tissue therapy, diagnosis squamous cell carcinoma I, II, III 35 35, 0 68.71 ± 7.46 – tumor vs. adjacent normal tissue 35 35, 0 68.71 ± 7.46 –
Fahrmann et al. 2015 – plasma diagnosis adenocarcinoma I, II, III, IV 43 21, 22 67.3 ± 10.10 – healthy 43 21, 22 65.9 ± 8.05 –
Wikoff et al. 2015b – tissue diagnosis adenocarcinoma I 39 15, 24 72.33 ± 8.78 smoker, non-smoker tumor vs. adjacent normal tissue 39 15, 24 72.33 ± 8.78 smoker, non-smoker
Reference Chromatography Ion source Positive/Negative mode Mass analyzer Identification level
Roś-Mazurczyk et al. 2017 GC – – TOF In-source fragmentation
Fahrmann et al. 2015 GC EI – TOF –
Fahrmann et al. 2015 GC EI – TOF –
Miyamoto et al. 2015 GC EI – TOF MS/MS
Miyamoto et al. 2015 GC EI – TOF MS/MS
Moreno et al. 2018 LC, GC ESI, EI positive, negative LC: linear ion‐trap, GC: single‐quadrupole LC: MS/MS
Mazzone et al. 2016 GC EI – quadrupole MS/MS
Fahrmann et al. 2015 GC EI – TOF –
Moreno et al. 2018 LC, GC ESI, EI positive, negative LC: linear ion‐trap, GC: single‐quadrupole LC: MS/MS
Fahrmann et al. 2015 GC EI – TOF –
Wikoff et al. 2015b GC EI – TOF –
Reference Data processing software Database search
Roś-Mazurczyk et al. 2017 Leco ChromaTOF-GC Replib, Mainlib and Fiehn libraries
Fahrmann et al. 2015 – UC Davis Metabolomics BinBase database
Fahrmann et al. 2015 – UC Davis Metabolomics BinBase database
Miyamoto et al. 2015 ChromaTOF software (Leco) UC Davis Metabolomics BinBase database
Miyamoto et al. 2015 ChromaTOF software (Leco) UC Davis Metabolomics BinBase database
Moreno et al. 2018 – KEGG, HMDB
Mazzone et al. 2016 Metabolon LIMS system Metabolon LIMS system
Fahrmann et al. 2015 – UC Davis Metabolomics BinBase database
Moreno et al. 2018 – KEGG, HMDB
Fahrmann et al. 2015 – UC Davis Metabolomics BinBase database
Wikoff et al. 2015b BinBase NIST11, BinBase
Reference Difference method Mean concentration (case) Mean concentration (control) Fold change (case/control) P-value FDR VIP
Roś-Mazurczyk et al. 2017 two-sample T test, U Mann-Whitney test, Benjamini-Hochberg approach 11.743 ± 7.108 11.998 ± 8.638 0.978746457742957 0.79547 0.85012 –
Fahrmann et al. 2015 regress (by the covariates: age, gender and smoking history [packs per year]), permutation test 10848 ± 5435 11979 ± 5203 0.91 0.64 0.874 –
Fahrmann et al. 2015 regress (by the covariates: age, gender and smoking history [packs per year]), permutation test 11324 ± 4806 13410 ± 5674 0.84 0.635 0.819 –
Miyamoto et al. 2015 Analysis of Covariance 92187.8181818182 88164 1.04564014996845 0.531017589459075 – –
Miyamoto et al. 2015 Analysis of Covariance 95587.3888888889 85305.45 1.12053085575293 0.437208228389904 – –
Moreno et al. 2018 paired two‐sample t‐test, PLS-DA – – 0.937942913871908 0.150430427248231 0.205728839756926 –
Mazzone et al. 2016 two- sample independent t test 1.0200968± 0.3469864 0.9498011± 0.3815291 1.07401096924398 0.1331728 0.230609873 –
Fahrmann et al. 2015 regress (by the covariates: age, gender and smoking history [packs per year]), permutation test 12259 ± 6475 15142 ± 7933 0.81 0.053 0.265 –
Moreno et al. 2018 paired two‐sample t‐test, PLS-DA – – 0.933325701515037 0.0389948811741565 0.0506806436107116 –
Fahrmann et al. 2015 regress (by the covariates: age, gender and smoking history [packs per year]), permutation test 6630 ± 3591 8125 ± 3432 0.82 0.017 0.102 –
Wikoff et al. 2015b OPLS-DA – – 1.2 – 0.037 –
Reference Classification method Cutoff value AUROC 95%CI Sensitivity (%) Specificity (%) Accuracy (%)
Roś-Mazurczyk et al. 2017 ROC curve – – – – –
Fahrmann et al. 2015 random forest – – – – –
Fahrmann et al. 2015 random forest – – – – –
Miyamoto et al. 2015 – – – – – –
Miyamoto et al. 2015 – – – – – –
Moreno et al. 2018 – – – – – –
Mazzone et al. 2016 – – – – – –
Fahrmann et al. 2015 random forest – – – – –
Moreno et al. 2018 – – – – – –
Fahrmann et al. 2015 random forest – – – – –
Wikoff et al. 2015b – – – – – –