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Citation Information

Cancer Prev Res (Phila). 2015 May;8(5):410-8. doi: 10.1158/1940-6207.CAPR-14-0329. Epub 2015 Feb 5.
Metabolomic markers of altered nucleotide metabolism in early stage adenocarcinoma.
Wikoff WR, Grapov D, Fahrmann JF, DeFelice B, Rom WN, Pass HI, Kim K, Nguyen U, Taylor SL, Gandara DR, Kelly K, Fiehn O, Miyamoto S.

Analytical methods
Comparative study	#1
Chromatography	GC
Ion source	EI
Positive/Negative mode	–
Mass analyzer	TOF
Identification level	–

Sample information
Comparative study		#1
Country		US
Specimen		tissue
Marker function		diagnosis
Participants(Case)	Cancer type	adenocarcinoma
	Stage	I
	Number	39
	Gender (M,F)	15, 24
	Mean age (range) (M,F)	72.33 ± 8.78
	Smoking status	smoker, non-smoker
Participants(Control)	Type	tumor vs. adjacent normal tissue
	Number	39.0
	Gender (M,F)	15, 24
	Mean age (range) (M,F)	72.33 ± 8.78
	Smoking status	smoker, non-smoker

Data processing and metabolite identification
Data processing software	BinBase
Database search	NIST11, BinBase

Statistics and concentration information
Differential analysis method	OPLS-DA
Classification method	–
Survival analysis method	–

Metabolites identified in the paper

Differential analysis method
Classification method

Show entries

Metabolite	Comparative study	Author-emphasized biomarkers	Mean concentration (case)	Mean concentration (control)	Fold change (case/control)	P-value	FDR	VIP
5,6-dihydrouracil	–	V	–	–	2.4	–	0.00000024	–
5'-deoxy-5'-methylthioadenosine	–	V	–	–	1.8	–	0.000065	–
alpha-tocopherol	–	V	–	–	2.2	–	0.00000041	–
gamma-tocopherol	–	V	–	–	1.2	–	0.01	–
glucose	–	V	–	–	2	–	0.00037	–
xanthine	–	V	–	–	2.7	–	0.00038	–
1,5-anhydroglucitol	–	–	–	–	1.2	–	0.037	–
1-hexadecanol	–	–	–	–	1	–	0.441	–
1-monopalmitin	–	–	–	–	1.1	–	0.047	–
1-monostearin	–	–	–	–	1.2	–	0.047	–

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Show entries

Metabolite	Comparative study	Author-emphasized biomarkers	Cutoff value	AUROC (95%CI)	Sensitivity (%)	Specificity (%)	Accuracy (%)
5,6-dihydrouracil	–	V	–	–	–	–	–
5'-deoxy-5'-methylthioadenosine	–	V	–	–	–	–	–
alpha-tocopherol	–	V	–	–	–	–	–
gamma-tocopherol	–	V	–	–	–	–	–
glucose	–	V	–	–	–	–	–
xanthine	–	V	–	–	–	–	–
1,5-anhydroglucitol	–	–	–	–	–	–	–
1-hexadecanol	–	–	–	–	–	–	–
1-monopalmitin	–	–	–	–	–	–	–
1-monostearin	–	–	–	–	–	–	–

Previous1 2 3 4 5…19Next

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