Showing information for HMDB0001859 ('4-acetamidophenol', 'paracetamol')


Metabolite information

HMDB ID HMDB0001859
Synonyms
4'-Hydroxyacetanilide
4-(acetylamino)Phenol
4-Acetamidophenol
4-Acetaminophenol
4-Hydroxyacetanilide
4-Hydroxyanilid kyseliny octove
A.F. anacin
APAP
Abenol
Abensanil
Abrol
Abrolet
Acamol
Accu-tap
Acenol
Acephen
Acertol
Aceta elixir
Aceta tablets
Acetagesic
Acetalgin
Acetaminofen
Acetaminophen uniserts
Acetaminophene
Acetamol
Acetofen
Actamin
Actamin extra
Actamin super
Actifed plus
Actimol chewable tablets
Actimol children's suspension
Actimol infants' suspension
Actimol junior strength caplets
Actron
Afebrin
Afebryl
Aferadol
Algesidal
Algina
Algomol
Algotropyl
Allay
Alpiny
Alpinyl
Alvedon
Amadil
Aminofen
Aminofen max
Anacin-3
Anacin-3 extra strength
Anadin dla dzieci
Anaflon
Analter
Anapap
Andox
Anelix
Anexsia
Anexsia 10/660
Anexsia 5/325
Anexsia 7.5/325
Anexsia 7.5/650
Anhiba
Anoquan
Anti-algos
Antidol
Apacet
Apacet capsules
Apacet elixir
Apacet extra strength caplets
Apacet extra strength tablets
Apacet regular strength tablets
Apadon
Apamid
Apamide
Apitrelal
Arfen
Asetam
Asomal
Aspac
Aspirin free anacin maximum strength caplets
Aspirin free anacin maximum strength gel caplets
Aspirin free anacin maximum strength tablets
Aspirin-free anacin
Aspirin-free excedrin caplets
Asplin
Atasol caplets
Atasol drops
Atasol forte caplets
Atasol forte tablets
Atasol oral solution
Atasol tablets
Atralidon
Babikan
Bacetamol
Bancap
Bancap HC
Banesin
Bayer select allergy-sinus
Bayer select head cold
Bayer select headache pain
Bayer select maximum strength headache pain relief formula
Bayer select menstrual multi-symptom
Bayer select sinus pain relief
Ben-u-ron
Benmyo
Bickie-mol
Biocetamol
Bucet
Butalbital
Butapap
CO-Gesic
COD-Acamol forte
Cadafen
Calapol
Calmanticold
Calpol
Capital with codeine
Captin
Causalon
Cefalex
Cetadol
Children'S acetaminophen elixir drops
Children'S acetaminophen oral solution
Children'S tylenol chewable
Claradol codeine
Clixodyne
Codabrol
Codalgin
Codapane
Codicet
Codisal
Codisal forte
Codoliprane
Codral pain relief
Cofamol
Conacetol
Contac cough & sore throat formula
Contra-schmerz P
Coricidin
Coricidin D
Coricidin sinus
Cosutone
Croix blanche
Cuponol
Curadon
Curpol
Custodial
DHC Plus
Dapa X-S
Darocet
Darvocet
Darvocet-N 50
Datril
Datril extra-strength
Daygrip
Demilets
Deminofen
Democyl
Demogripal
Desfebre
Dhamol
Dial-a-gesic
Dial-alpha-gesic
Dimindol
Dirox
Disprol
Dol-stop
Dolcor
Dolefin
Dolegrippin
Dolene ap-65
Dolgesic
Doliprane
Dolko
Dolofugin
Doloreduct
Dolorfug
Dolorol forte
Dolorstop
Dolotec
Dolprone
Dorocoff
Dresan
Dristan cold no drowsiness
Dristancito
Duracetamol
Duradyne DHC
Durapan
Dymadon
Dymadon co
Dymadon forte
Dypap
Ecosetol
Elixodyne
Empracet
Endecon
Enelfa
Eneril
Esgic
Esgic-plus
Eu-med
Excedrin
Excedrin caplets
Excedrin extra strength caplets
Excipain
Exdol
Exdol strong
Fanalgic
Farmadol
Febranine
Febrectal
Febrectol
Febrex
Febricet
Febridol
Febrilix
Febrin
Febrinol
Febrolin
Femcet
Fendon
Fensum
Fepanil
Feverall junior strength
Feverall sprinkle caps junior strength
Fevor
Finimal
Finiweh
Fioricet
Fluparmol
Fortalidon P
Freka-cetamol
Gattaphen T
Gelocatil
Geluprane
Genapap children's elixir
Genapap children's tablets
Genapap extra strength caplets
Genapap extra strength tablets
Genapap regular strength tablets
Genebs X-tra
Genebs extra strength caplets
Genebs regular strength tablets
Geralgine-P
Gripin bebe
Grippostad
Gynospasmine
Hedex
Helon N
Homoolan
Hy-phen
Hycomine compound
Hydrocet
Ildamol
Inalgex
Infadrops
Infants' feverall
Influbene N
Injectapap
Intensin
Janupap
Junior disprol
Kataprin
Kinder finimal
Korum
Kratofin simplex
Labamol
Lekadol
Lemgrip
Lemsip
Lestemp
Liquagesic
Liquigesic co
Liquiprin
Liquiprin children's elixir
Liquiprin infants" drops
Lonarid
Lonarid mono
Lorcet-HD
Lortab
Lupocet
Lyteca
Lyteca syrup
Magnidol
Malex N
Malgis
Malidens
Maxadol
Medigesic plus
Medinol paediatric
Medocodene
Melabon infantil
Mexalen
Midol PM night time formula
Midol maximum strength
Midol regular strength
Midol teen formula
Migraleve yellow
Minafen
Minoset
Miralgin
Momentum
Multin
N-(4-Hydroxyphenyl)acetamide
N-Acetyl-4-aminophenol
N-Acetyl-P-aminophenol
NAPA
NO-Febril
Naldegesic
Napafen
Napap
Naprinol
Nealgyl
Nebs
NeoCitran
Neodol
Neodolito
Neopap
Neotrend
Neuridon
New cortal for children
NilnOcen
Nina
Nobedon
Nodolex
Noral
Norcet
Norco
O-Acetaminophenol
Oltyl
Oralgan
Oraphen-PD
Ortensan
Oxycet
Oxycocet
Oxycodone 2.5/apap 500
Oxycodone 5/apap 500
P-(acetylamino)Phenol
P-Acetamidophenol
P-Acetaminophenol
P-Acetylaminophenol
P-Hydroxyacetanilide
P-Hydroxyphenolacetamide
PCM Paracetamol lichtenstein
Paceco
Pacemo
Pacemol
Pacet
Pacimol
Paedialgon
Paedol
Painex
Paldesic
Pamol
Panacete
Panadeine
Panadeine co
Panadiene
Panadol
Panadol extra strength
Panadol junior strength caplets
Panadol maximum strength caplets
Panadol maximum strength tablets
Panaleve
Panamax
Panasorb
Panasorbe
Panets
Panex
Panodil
Panofen
Pantalgin
Papa-deine #3
Papa-deine #4
Para-suppo
Para-tabs
Paracemol
Paracenol
Paracet
Paracetamol
Paracetamol BC
Paracetamol DC
Paracetamol PB
Paracetamol al
Paracetamol antipanin P
Paracetamol basics
Paracetamol dr. schmidgall
Paracetamol fecofar
Paracetamol genericon
Paracetamol hanseler
Paracetamol harkley
Paracetamol heumann
Paracetamol hexal
Paracetamol italfarmaco
Paracetamol nycomed
Paracetamol raffo
Paracetamol ratiopharm
Paracetamol rosch
Paracetamol saar
Paracetamol smithkline beecham
Paracetamol stada
Paracetamol von CT
Paracetamol winthrop
Paracetamole
Paracetamolo
Paracetamolum
Paracetanol
Paracetol
Paracin
Paracod
Paracodol
Parador
Paradrops
Parakapton
Parake
Paralen
Paralief
Paralink
Paralyoc
Paramol
Paramolan
Paranox
Parapan
Parasedol
Parasin
Paraspen
Parcetol
Parelan
Parmol
Parogal
Paroma
Pasolind
Pasolind N
Pe-tam
Pediapirin
Pediatrix
Pedric
Percocet
Percocet-5
Percocet-demi
Percogesic with codeine
Perdolan mono
Phenaphen
Phenaphen caplets
Phenaphen w/codeine
Phendon
Phenipirin
Phogoglandin
Phrenilin
Phrenilin forte
Pinex
Piramin
Pirinasol
Plicet
Polmofen
Predimol
Predualito
Prestwick_13
Prodol
Prompt
Prontina
Propacet
Propacet 100
Proval #3
Puernol
Pulmofen
Pyregesic-C
Pyrigesic
Pyrinazine
Pyromed
Quiet world
Redutemp
Reliv
Remedol
Rhinex D-lay tablets
Rivalgyl
Robigesic
Robitussin night relief
Rockamol plus
Rounox
Roxicet
Roxicet 5/500
Roxilox
RubieMol
Rubophen
Rupemol
SK-Apap
ST Joseph aspirin-free
ST Joseph aspirin-free for children
Salzone
Sanicet
Sanicopyrine
Scanol
Scentalgyl
Scherzatabletten rezeptur 534
Schmerzex
Sedalito
Sedapap
Semolacin
Servigesic
Seskamol
Setakop
Setamol
Setol
Sifenol
Sinaspril
Sine-OFF sinus medicine caplets
Sinedol
Sinmol
Sinubid
Snaplets-FR
Spalt N
Spalt fur die nacht
St. joseph cold tablets for children
St. joseph fever reducer
Stanback
Stopain
Sudafed severe cold formula
Sudafed sinus
Sunetheton
Supac
Supadol mono
Supofen
Suppap
Suppap-120
Suppap-325
Suppap-650
Supramol-m
Synalgos-DC-a
TYL
Tabalgin
Tachiprina
Talacen
Tapanol extra strength caplets
Tapanol extra strength tablets
Tapar
Tavist allergy/sinus/headache
Tazamol
Temlo
Tempanal
Tempra
Tempra caplets
Tempra chewable tablets
Tempra d.s
Tempra drops
Tempra syrup
Tencon
Termacet
Termalgin
Termalgine
Termofren
TheraFlu
Tibinide
Tibizide
Tiffy
Tisin
Tisiodrazida
Titralgan
Tizide
Tocris-1706
Toximer P
Tralgon
Treupel N
Treupel mon
Treuphadol
Triad
Triaminic sore throat formula
Triaprin
Tricoton
Tussapap
Tycolet
Tylenol
Tylenol allergy sinus
Tylenol arthritis extended relief
Tylenol caplets
Tylenol children's chewable tablets
Tylenol children's elixir
Tylenol children's suspension liquid
Tylenol drops
Tylenol elixir
Tylenol extra strength adult liquid pain reliever
Tylenol extra strength caplets
Tylenol extra strength gelcaps
Tylenol extra strength tablets
Tylenol gelcaps
Tylenol infants drops
Tylenol infants" suspension drops
Tylenol junior strength caplets
Tylenol junior strength chewable tablets
Tylenol regular strength caplets
Tylenol regular strength tablets
Tylenol tablets
Tylex
Tylex CD
Tylol
Tylox
Tylox-325
Tymol
Ultracet
Upsanol
Utragin
Valadol
Valgesic
Valorin
Valorin extra
Vanquish
Veralgina
Vermidon
Verpol
Viclor richet
Vicodin
Vicodin HP
Vicodin es
Vips
Viruflu
Vivimed
Volpan
Wygesic
Zatinol
Zolben
a-Per
alpha-Per
apo-Acetaminophen
febro-Gesic
mono Praecimed
neo-Fepramol
panado-Co
panado-co Caplets
Chemical formula C8H9NO2
IUPAC name
N-(4-hydroxyphenyl)acetamide
CAS registry number 103-90-2
Monoisotopic molecular weight 151.063328537

Chemical taxonomy

Super class Benzenoids
Class Phenols
Sub class 1-hydroxy-2-unsubstituted benzenoids

Biological properties

Pathways (Pathway Details in HMDB)

The paper(s) that report HMDB0001859 as a lung cancer biomarker

The studies that identify HMDB0001859 as a lung cancer-related metabolite


Reference Country Specimen Marker function Participants (Case) Participants (Control)
Cancer type Stage Number Gender (M,F) Age mean (range) (M/F) Smoking status Type Number Gender (M,F) Age mean (range) (M/F) Smoking status
Mazzone et al. 2016 US serum adenocarcinoma, squamous cell carcinoma I, II, III 94 55.3%, 44.7% 68.7 at-risk controls 190 50.5%, 49.5% 66.2
Fahrmann et al. 2015 US serum diagnosis adenocarcinoma I, II, III, IV 49 17, 32 65.9 ± 9.87 healthy 31 11, 20 64.1 ± 8.97
Fahrmann et al. 2015 US plasma diagnosis adenocarcinoma I, II, III, IV 43 21, 22 67.3 ± 10.10 healthy 43 21, 22 65.9 ± 8.05
Fahrmann et al. 2015 US serum diagnosis adenocarcinoma I, II, III, IV 43 21, 22 67.3 ± 10.10 healthy 43 21, 22 65.9 ± 8.05
Fahrmann et al. 2015 US plasma diagnosis adenocarcinoma I, II, III, IV 52 17, 35 65.9 ± 9.66 healthy 31 11, 20 64.1 ± 8.97
Moreno et al. 2018 Spain tissue therapy, diagnosis adenocarcinoma I, II, III 33 24, 9 62.11 ± 9.73 tumor vs. adjacent normal tissue 33 24, 9 62.11 ± 9.73
Moreno et al. 2018 Spain tissue therapy, diagnosis squamous cell carcinoma I, II, III 35 35, 0 68.71 ± 7.46 tumor vs. adjacent normal tissue 35 35, 0 68.71 ± 7.46
Sun et al. 2019 China serum diagnosis lung cancer I, II, III, IV 31 21, 10 54.1 ± 9.9 smoker, non-smoker healthy 29 15, 14 52.1 ± 14.6 smoker, non-smoker
Reference Chromatography Ion source Positive/Negative mode Mass analyzer Identification level
Mazzone et al. 2016 LC ESI positive linear ion-trap MS/MS
Fahrmann et al. 2015 GC EI TOF
Fahrmann et al. 2015 GC EI TOF
Fahrmann et al. 2015 GC EI TOF
Fahrmann et al. 2015 GC EI TOF
Moreno et al. 2018 LC, GC ESI, EI both LC: linear ion-trap, GC: single-quadrupole LC: MS/MS
Moreno et al. 2018 LC, GC ESI, EI both LC: linear ion-trap, GC: single-quadrupole LC: MS/MS
Sun et al. 2019 GC
Reference Data processing software Database search
Mazzone et al. 2016 Metabolon LIMS system Metabolon LIMS system
Fahrmann et al. 2015 UC Davis Metabolomics BinBase database
Fahrmann et al. 2015 UC Davis Metabolomics BinBase database
Fahrmann et al. 2015 UC Davis Metabolomics BinBase database
Fahrmann et al. 2015 UC Davis Metabolomics BinBase database
Moreno et al. 2018 KEGG, HMDB
Moreno et al. 2018 KEGG, HMDB
Sun et al. 2019 BinBase, KEGG
Reference Difference method Mean concentration (case) Mean concentration (control) Fold change (case/control) P-value FDR VIP
Mazzone et al. 2016 two- sample independent t test 0.7151638± 1.5846529 0.3297916± 0.9786866 2.17 0.01 0.04
Fahrmann et al. 2015 regress (by the covariates: age, gender and smoking history [packs per year]), permutation test 1296 ± 3528 335 ± 729 3.86 0.30 0.62
Fahrmann et al. 2015 regress (by the covariates: age, gender and smoking history [packs per year]), permutation test 213 ± 485 175 ± 370 1.22 0.68 0.85
Fahrmann et al. 2015 regress (by the covariates: age, gender and smoking history [packs per year]), permutation test 337 ± 684 322 ± 721 1.05 0.96 0.99
Fahrmann et al. 2015 regress (by the covariates: age, gender and smoking history [packs per year]), permutation test 901 ± 2421 285 ± 741 3.16 0.22 0.59
Moreno et al. 2018 paired two-sample t-test, PLS-DA 1.06 0.26 0.33
Moreno et al. 2018 paired two-sample t-test, PLS-DA 0.99 0.95 0.95
Sun et al. 2019 Student t test, PLS-DA 4.73 2.86e-11 1.21e-10 1.23
Reference Classification method Cutoff value AUROC 95%CI Sensitivity (%) Specificity (%) Accuracy (%)
Mazzone et al. 2016
Fahrmann et al. 2015 random forest
Fahrmann et al. 2015 random forest
Fahrmann et al. 2015 random forest
Fahrmann et al. 2015 random forest
Moreno et al. 2018
Moreno et al. 2018
Sun et al. 2019 ROC curve analysis