Introduction
Update History
p53BLD collected 13 publicly available TP53 ChIP-seq datasets derived from different normal and cancer cell lines harboring either the WT or mutant GOF TP53.
p53BLD provides
• a browse mode to visualize the binding loci of TP53 in the genome
• a search mode to retrieve genes whose promoters are bound by TP53
| DATASET | CELL LINE | TP53 | TREATMENT | GEO |
|---|---|---|---|---|
| D1 | Neonatal foreskin keratinocytes | WT | None | GSM1366689 |
| D2 | Neonatal foreskin keratinocytes | WT | Adrimycin | GSM1366690 |
| D3 | Neonatal foreskin keratinocytes | WT | Cisplatin | GSM1366691 |
| D4 | Normal human lung fibroblast (IMR90) | WT | 5FU | GSE31558 |
| D5 | Colon cancer cell line (HCT116) | WT | 5FU | GSE58714 |
| D6 | Osteosarcoma cell line (U2OS) | WT | Actinomycin D | GSM545807 |
| D7 | Osteosarcoma cell line (U2OS) | WT | Etoposide | GSM545808 |
| D8 | Breast cancer cell line (MCF7) | WT | None | GSM1429753 |
| D9 | Breast cancer cell line (MDA-MB-175VII) | WT | None | GSM1429754 |
| D10 | Breast cancer cell line (HCC70) | R248Q | None | GSM1429756 |
| D11 | Breast cancer cell line (BT-549) | R249S | None | GSM1429757 |
| D12 | Breast cancer cell line (MDA-MB-468) | R273H | None | GSM1429755 |
| D13 | Li-Fraumeni fibroblast (MDA-H087) | R248W | None | GSE36749 |
p53BLD provides
• a browse mode to visualize the binding loci of TP53 in the genome
• a search mode to retrieve genes whose promoters are bound by TP53
Update History
2018 May: Release p53BLD.
2018 Apr.: Add a download page.
2017 Dec.: Develop the web interface of p53BLD.
2017 Sept.: Download and process the 13 publicly available ChIP-seq datasets of TP53.
2017 May: Start p53BLD project.
Last Updated: May 4, 2018.
2018 Apr.: Add a download page.
2017 Dec.: Develop the web interface of p53BLD.
2017 Sept.: Download and process the 13 publicly available ChIP-seq datasets of TP53.
2017 May: Start p53BLD project.
Last Updated: May 4, 2018.