Showing information for HMDB0007970 ('PC(16:0/18:0)')

Metabolite information
HMDB ID HMDB0007970
Synonyms
1-Palmitoyl-2-stearoyl-sn-glycero-3-phosphorylcholine
1-Palmitoyl-2-stearoylphosphatidylcholine
1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine
1-palmitoyl-2-stearoyl-sn-glycero-3-phosphocholine
Cellular membrane
Dietary supplement
Digestion
Extracellular region
Fauna
Inner membrane
Lecithin
Lipid metabolic process
Membrane integrity agent
Membrane stability agent
Nutraceutical
PC[16:0/18:0]
PC[34:0]
Phosphatidylcholine[16:0/18:0]
Phosphatidylcholine[34:0]
Signal transduction
Surface-active agent
[2R]-3-[Palmitoyloxy]-2-[stearoyloxy]propyl 2-[trimethylammonio]ethyl phosphate
[2R]-3-[Palmitoyloxy]-2-[stearoyloxy]propyl 2-[trimethylammonio]ethyl phosphoric acid
gpcho[16:0/18:0]
gpcho[34:0]
Chemical formula C42H84NO8P
IUPAC name
(2-{[(2R)-3-(hexadecanoyloxy)-2-(octadecanoyloxy)propyl phosphonato]oxy}ethyl)trimethylazanium
CAS registry number –
Monisotopic molecular weight 761.593455181

Chemical taxonomy
Super class Lipids and lipid-like molecules
Class Glycerophospholipids
Sub class Glycerophosphocholines

Biological properties
Pahtways
Author-emphasized biomarker in the paper(s)

Lung cancer metabolomics studies that identify HMDB0007970 ('PC(16:0/18:0)')

Reference Country Specimen Marker function Participants (Case) Participants (Control)
Cancer type Stage Number Gender (M,F) Age mean (range) (M/F) Smoking status Type Number Gender (M,F) Age mean (range) (M/F) Smoking status
Chen et al. 2018 – serum diagnosis NSCLC I, II 90 40, 50 58.1 ± 9.0 – healthy 90 42, 48 53.0 ± 11.8 –
Callejón-Leblic et al. 2019 – blood diagnosis NSCLC, SCLC II, III, IV 30 25, 5 67 ± 12 former, current, non-smoker healthy 30 14, 16 56 ± 14 former, non-smoker
Reference Chromatography Ion source Positive/Negative mode Mass analyzer Identification level
Chen et al. 2018 LC ESI positive/ negative Q-TOF –
Callejón-Leblic et al. 2019 DI ESI positive Q-TOF MS/MS
Reference Data processing software Database search
Chen et al. 2018 Analyst TF, XCMS –
Callejón-Leblic et al. 2019 – HMDB, Metlin
Reference Difference method Mean concentration (case) Mean concentration (control) Fold change (case/control) P-value FDR VIP
Chen et al. 2018 Student’s t-test 140.06 ng/mL 117.01 ng/mL – 0.066 0.0729 –
Callejón-Leblic et al. 2019 PCA, PLS-DA, one-way ANOVA – – 1.67 0.014 – 1.17
Reference Classification method Cutoff value AUROC 95%CI Sensitivity (%) Specificity (%) Accuracy (%)
Chen et al. 2018 ROC curve – – – – –
Callejón-Leblic et al. 2019 ROC curve – 0.67 – – –