Metabolite information |
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| HMDB ID | - |
| Synonyms |
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| Chemical formula | - |
| IUPAC name | - |
| CAS registry number | - |
| Monisotopic molecular weight | - |
Chemical taxonomy |
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| Super class | - |
| Class | - |
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Biological properties |
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| Pahtways |
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| Author-emphasized biomarker in the paper(s) |
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| Reference | Country | Specimen | Marker function | Participants (Case) | Participants (Control) | |||||||||
| Cancer type | Stage | Number | Gender (M,F) | Age mean (range) (M/F) | Smoking status | Type | Number | Gender (M,F) | Age mean (range) (M/F) | Smoking status | ||||
| Ni et al. 2019 | – | serum | diagnosis | lung cancer | – | 40 | 26, 14 | 66.7 (49-83) | – | healthy | 100 | 65, 35 | 64.1 (41-90) | – |
| Ni et al. 2019 | – | serum | diagnosis | NSCLC, SCLC | II, III, IV | 17 | 13, 4 | 66.3 (53-77) | former, current, non-smoker | healthy | 30 | 23, 7 | 62.8 (34-85) | former, current, non-smoker |
| Reference | Chromatography | Ion source | Positive/Negative mode | Mass analyzer | Identification level |
| Ni et al. 2019 | LC | ESI | positive | triple quadrupole | MS/MS |
| Ni et al. 2019 | LC | ESI | positive | triple quadrupole | MS/MS |
| Reference | Data processing software | Database search |
| Ni et al. 2019 | – | HMDB, KEGG, SMPDB |
| Ni et al. 2019 | – | HMDB, KEGG, SMPDB |
| Reference | Difference method | Mean concentration (case) | Mean concentration (control) | Fold change (case/control) | P-value | FDR | VIP |
| Ni et al. 2019 | Mann-Whitney U test, Student's t-test, Welch's F test | 0.04 | 0.02 | – | <0.001 | – | – |
| Ni et al. 2019 | Mann-Whitney U test, Student's t-test, Welch's F test | 0.03 | 0.02 | – | 0.805 | – | – |
| Reference | Classification method | Cutoff value | AUROC 95%CI | Sensitivity (%) | Specificity (%) | Accuracy (%) |
| Ni et al. 2019 | ROC analysis | – | 0.761 | – | – | – |
| Ni et al. 2019 | ROC analysis | – | 0.52 | – | – | – |