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Exp Ther Med. 2019 Jul;18(1):188-198. doi: 10.3892/etm.2019.7533. Epub 2019 Apr 30.
Targeted metabolomics for serum amino acids and acylcarnitines in patients with lung cancer.
Ni J,, Xu L, Li W, Zheng C, Wu L.

Analytical methods
Comparative study	#1	#2
Chromatography	LC	LC
Ion source	ESI	ESI
Positive/Negative mode	positive	positive
Mass analyzer	triple quadrupole	triple quadrupole
Identification level	MS/MS	MS/MS

Sample information
Comparative study		#1	#2
Country		China	China
Specimen		serum	serum
Marker function		diagnosis	diagnosis
Participants(Case)	Cancer type	lung cancer	NSCLC, SCLC
	Stage	–	II, III, IV
	Number	40	17
	Gender (M,F)	26, 14	13, 4
	Mean age (range) (M,F)	66.7 (49-83)	66.3 (53-77)
	Smoking status	–	former, current, non-smoker
Participants(Control)	Type	healthy	healthy
	Number	100.0	30.0
	Gender (M,F)	65, 35	23, 7
	Mean age (range) (M,F)	64.1 (41-90)	62.8 (34-85)
	Smoking status	–	former, current, non-smoker

Data processing and metabolite identification
Data processing software	–
Database search	HMDB, KEGG, SMPDB

Statistics and concentration information
Differential analysis method	Mann-Whitney U test, Student's t-test, Welch's F test
Classification method	ROC analysis
Survival analysis method	–

Metabolites identified in the paper

Differential analysis method
Classification method

Show entries

Metabolite	Comparative study	Author-emphasized biomarkers	Mean concentration (case)	Mean concentration (control)	Fold change (case/control)	P-value	FDR	VIP
arginine	–	V	224.94	119.51	–	<0.001	–	–
citrulline	–	V	23.41	40.8	–	<0.001	–	–
methionine	–	V	21.02	32.55	–	<0.001	–	–
valine	–	V	136.6	165.03	–	<0.001	–	–
methionine	–	V	27.22	30.24	–	0.027	–	–
arginine	–	V	139.89	119.89	–	0.012	–	–
citrulline	–	V	32	37.12	–	0.01	–	–
valine	–	V	150.73	171.69	–	0.009	–	–
C14-carnitine	–	–	0.04	0.02	–	<0.001	–	–
C16-carnitine	–	–	0.38	0.17	–	<0.001	–	–

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Show entries

Metabolite	Comparative study	Author-emphasized biomarkers	Cutoff value	AUROC (95%CI)	Sensitivity (%)	Specificity (%)	Accuracy (%)
arginine	–	V	–	0.907	–	–	–
citrulline	–	V	–	0.103	–	–	–
methionine	–	V	–	0.076	–	–	–
valine	–	V	–	0.183	–	–	–
methionine	–	V	–	0.316	–	–	–
arginine	–	V	–	0.716	–	–	–
citrulline	–	V	–	0.277	–	–	–
valine	–	V	–	0.299	–	–	–
C14-carnitine	–	–	–	0.761	–	–	–
C16-carnitine	–	–	–	0.858	–	–	–

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