Metabolite information |
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| HMDB ID | HMDB0003424 |
| Synonyms |
1-Cetanol1-Hexadecyl alc1-Hexadecyl alcohol1-Hexanedecanol1-Hydroxyhexadecane16-HexadecanolAdolAdol 52Adol 52 NFAdol 52nfAdol 54Alcohol C-16Aldol 54Alfol 16Beautification productC16 AlcoholCachalot C-50Cachalot C-50 NFCachalot C-51Cachalot C-52Cellular membraneCeraphyl icaCetaffineCetalCetalol caCetanolCetostearyl alcoholCetyl alcoholCetyl alcohol NFCetyl alcohol, 14C-labeledCetyl alcohol, aluminum saltCetylalkoholCetylic alcoholCetylolCrodacol CCrodacol C70Crodacol C95NFCrodacol-casCrodacol-catCucurbitsCyclal cetyl alcoholCytoplasmaDehydag wax 16DigestionDytol F-11Elfacos CEpal 16nfEthalEtholEutanol g16Extracellular regionExxal 16FaecalFaecesFancol caFatty alcoholFecalFloraGourdsHexadecan-1-olHexadecanolHexadecanol NFHexadecyl alcoholHyfatolHyfatol 16Isocetyl alcoholIsohexadecanolIsohexadecyl alcoholLanette 16Lanol CLipid metabolic processLipocol CLorol 24Lorol C16LorolL 24Loxanol KLoxanol K extraLoxanwachs SKLoxiol VPG 1743Membrane integrity agentMembrane stability agentMichel xo-150-16Myristyl alcoholN-1-HexadecanolN-Cetyl alcoholN-Hexadecan-1-olN-HexadecanolN-Hexadecyl alcoholNormal primary hexadecyl alcoholPalmityl alcoholPcpPersonal hygienePhilcohol 1600Product 308Rita caSSDSSD RPSignal transductionSiponol CCSiponol wax-aStoolSurface-active agentToiletriesToiletryatalco C |
| Chemical formula | C16H34O |
| IUPAC name | hexadecan-1-ol |
| CAS registry number | 36653-82-4 |
| Monisotopic molecular weight | 242.26096571 |
Chemical taxonomy |
|
| Super class | Lipids and lipid-like molecules |
| Class | Fatty Acyls |
| Sub class | Fatty alcohols |
Biological properties |
|
| Pahtways |
Plasmalogen Synthesis |
| Author-emphasized biomarker in the paper(s) |
|
| Reference | Country | Specimen | Marker function | Participants (Case) | Participants (Control) | |||||||||
| Cancer type | Stage | Number | Gender (M,F) | Age mean (range) (M/F) | Smoking status | Type | Number | Gender (M,F) | Age mean (range) (M/F) | Smoking status | ||||
| Miyamoto et al. 2015 | – | blood | diagnosis | adenocarcinoma | unknown (mostly late stage) | 18 | 10, 8 | 67 (50-85) / 62 (53-72) | former, current | healthy | 20 | 8, 12 | 64 (49-80) / 66 (58-82) | former, current |
| Roś-Mazurczyk et al. 2017 | – | serum | diagnosis | adenocarcinoma, squamous cell carcinoma | I, II, III | 31 | 17, 14 | 52-72 | – | healthy | 92 | 52, 40 | 52-73 | – |
| Miyamoto et al. 2015 | – | blood | diagnosis | NSCLC, SCLC, mesothelioma, secondary metastasis to lung | I, II, III, IV | 11 | 4, 7 | 67 (61-73) / 67 (47-76) | smoker, non-smoker | healthy | 11 | 5, 6 | 69 (61-83) / 54 (44-61) | unknown |
| Wikoff et al. 2015b | – | tissue | diagnosis | adenocarcinoma | I | 39 | 15, 24 | 72.33 ± 8.78 | smoker, non-smoker | tumor vs. adjacent normal tissue | 39 | 15, 24 | 72.33 ± 8.78 | smoker, non-smoker |
| Reference | Chromatography | Ion source | Positive/Negative mode | Mass analyzer | Identification level |
| Miyamoto et al. 2015 | GC | EI | – | TOF | MS/MS |
| Roś-Mazurczyk et al. 2017 | GC | – | – | TOF | In-source fragmentation |
| Miyamoto et al. 2015 | GC | EI | – | TOF | MS/MS |
| Wikoff et al. 2015b | GC | EI | – | TOF | – |
| Reference | Data processing software | Database search |
| Miyamoto et al. 2015 | ChromaTOF software (Leco) | UC Davis Metabolomics BinBase database |
| Roś-Mazurczyk et al. 2017 | Leco ChromaTOF-GC | Replib, Mainlib and Fiehn libraries |
| Miyamoto et al. 2015 | ChromaTOF software (Leco) | UC Davis Metabolomics BinBase database |
| Wikoff et al. 2015b | BinBase | NIST11, BinBase |
| Reference | Difference method | Mean concentration (case) | Mean concentration (control) | Fold change (case/control) | P-value | FDR | VIP |
| Miyamoto et al. 2015 | Analysis of Covariance | 1598 | 1398.2 | 1.14289801172937 | 0.151229323233792 | – | – |
| Roś-Mazurczyk et al. 2017 | two-sample T test, U Mann-Whitney test, Benjamini-Hochberg approach | 0.35049 ± 0.18497 | 0.4707 ± 0.55204 | 0.744614404079031 | 0.037833 | 0.26483 | – |
| Miyamoto et al. 2015 | Analysis of Covariance | 1734.90909090909 | 1250.81818181818 | 1.38701940548005 | 0.00901555221616897 | – | – |
| Wikoff et al. 2015b | OPLS-DA | – | – | 1 | – | 0.441 | – |
| Reference | Classification method | Cutoff value | AUROC 95%CI | Sensitivity (%) | Specificity (%) | Accuracy (%) |
| Miyamoto et al. 2015 | – | – | – | – | – | – |
| Roś-Mazurczyk et al. 2017 | ROC curve | – | – | – | – | – |
| Miyamoto et al. 2015 | – | – | – | – | – | – |
| Wikoff et al. 2015b | – | – | – | – | – | – |