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Citation Information
Sci Rep. 2019 Jun 20;9(1):8916. doi: 10.1038/s41598-019-45506-3.
The Ratios of monounsaturated to saturated phosphatidylcholines in lung adenocarcinoma microenvironment analyzed by Liquid Chromatography-Mass spectrometry and imaging Mass spectrometry.
Muranishi Y, Sato T, Ito S, Satoh J, Yoshizawa A, Tamari S, Ueda Y,,, Yutaka Y,, Menju T, Nakamura T, Date H.
Analytical methods | ||
|---|---|---|
| Comparative study | #1 | |
| Chromatography | LC | |
| Ion source | ESI | |
| Positive/Negative mode | positive | |
| Mass analyzer | Q-TOF | |
| Identification level | MS/MS | |
Sample information | ||
|---|---|---|
| Comparative study | #1 | |
| Country | China | |
| Specimen | tissue | |
| Marker function | diagnosis | |
| Participants(Case) | Cancer type | adenocarcinoma |
| Stage | I | |
| Number | 25 | |
| Gender (M,F) | – | |
| Mean age (range) (M,F) | 46-82 | |
| Smoking status | – | |
| Participants(Control) | Type | tumor vs. adjacent normal tissue |
| Number | 25.0 | |
| Gender (M,F) | – | |
| Mean age (range) (M,F) | 46-82 | |
| Smoking status | – | |
Data processing and metabolite identification | |
|---|---|
| Data processing software | Progenesis QI |
| Database search | LIPID MAPS, HMDB |
Statistics and concentration information | |
|---|---|
| Differential analysis method | Student's t test |
| Classification method | – |
| Survival analysis method | – |
Metabolites identified in the paper
| Metabolite | Comparative study | Author-emphasized biomarkers | Mean concentration (case) | Mean concentration (control) | Fold change (case/control) | P-value | FDR | VIP |
|---|---|---|---|---|---|---|---|---|
| SM(42:2) | – | V | – | – | – | < 0.0001 | – | – |
| PC(16:0/18:1) | – | – | – | – | – | 0.2879 | – | – |
| PC(36:4) | – | – | – | – | – | 0.2545 | – | – |
| PC(16:0/16:0) | – | V | – | – | – | 0.0432 | – | – |
| Metabolite | Comparative study | Author-emphasized biomarkers | Cutoff value | AUROC (95%CI) | Sensitivity (%) | Specificity (%) | Accuracy (%) |
|---|---|---|---|---|---|---|---|
| SM(42:2) | – | V | – | – | – | – | – |
| PC(16:0/18:1) | – | – | – | – | – | – | – |
| PC(36:4) | – | – | – | – | – | – | – |
| PC(16:0/16:0) | – | V | – | – | – | – | – |
Paper graphical summary
