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Citation Information
J Cell Biochem. 2019 Feb 25. doi: 10.1002/jcb.28482. [Epub ahead of print]
Integration of metabolomic and transcriptomic profiles to identify biomarkers in serum of lung cancer.
Sun Q, Zhao W, Wang L, Guo F, Song D, Zhang Q, Zhang D, Fan Y, Wang J.
Analytical methods | ||
|---|---|---|
| Comparative study | #1 | |
| Chromatography | GC | |
| Ion source | – | |
| Positive/Negative mode | – | |
| Mass analyzer | – | |
| Identification level | – | |
Sample information | ||
|---|---|---|
| Comparative study | #1 | |
| Country | China | |
| Specimen | serum | |
| Marker function | diagnosis | |
| Participants(Case) | Cancer type | lung cancer |
| Stage | I, II, III, IV | |
| Number | 31 | |
| Gender (M,F) | 21, 10 | |
| Mean age (range) (M,F) | 54.1 ± 9.9 | |
| Smoking status | smoker, non-smoker | |
| Participants(Control) | Type | healthy |
| Number | 29.0 | |
| Gender (M,F) | 15, 14 | |
| Mean age (range) (M,F) | 52.1 ± 14.6 | |
| Smoking status | smoker, non-smoker | |
Data processing and metabolite identification | |
|---|---|
| Data processing software | – |
| Database search | BinBase, KEGG |
Statistics and concentration information | |
|---|---|
| Differential analysis method | Student t test, PLS-DA |
| Classification method | ROC curve analysis |
| Survival analysis method | – |
Metabolites identified in the paper
| Metabolite | Comparative study | Author-emphasized biomarkers | Mean concentration (case) | Mean concentration (control) | Fold change (case/control) | P-value | FDR | VIP |
|---|---|---|---|---|---|---|---|---|
| cystine | – | – | – | – | 0.717290784120464 | 0.004624 | 0.033975 | 1.047 |
| 3‐phosphoglycerate | – | – | – | – | 1.59975170055238 | 0.004035 | 0.030999 | 0.23804 |
| dodecanol | – | – | – | – | 0.732555514975969 | 0.001641 | 0.013205 | 1.0168 |
| caprylic acid | – | – | – | – | 0.665273743128804 | 0.001293 | 0.010923 | 1.0126 |
| azelaic acid | – | – | – | – | 2.39408271845162 | 0.000455 | 0.004052 | 0.65377 |
| urea | – | – | – | – | 1.52994310132377 | 0.000276 | 0.002596 | 0.15879 |
| lyxose | – | – | – | – | 0.542084627312226 | 0.000262 | 0.002596 | 1.0744 |
| maltose | – | – | – | – | 1.71977997334083 | 0.000228 | 0.002408 | 0.51667 |
| kynurenine | – | – | – | – | 1.86580213621981 | 0.00022 | 0.002408 | 0.54953 |
| naproxen | – | – | – | – | 0.718594600438878 | 0.000128 | 0.001542 | 1.1766 |
| palmitoleic acid | – | – | – | – | 2.12911223103956 | 0.000105 | 0.001368 | 0.73193 |
| salicylic acid | – | – | – | – | 5.80813102780905 | 0.0000646 | 0.000909 | 0.83921 |
| butane-2,3-diol | – | – | – | – | 2.12300386835431 | 0.0000581 | 0.000893 | 0.7573 |
| oleic acid | – | – | – | – | 2.20331077465311 | 0.00000895 | 0.000151 | 0.73145 |
| inosine | – | – | – | – | 0.539928396620536 | 0.00000673 | 0.000126 | 1.2696 |
| fructose | – | – | – | – | 0.401892065539033 | 0.0000045 | 0.0000951 | 1.2899 |
| 2‐Hydroxyhippuric acid | – | – | – | – | 3.83366958537594 | 0.0000000307 | 0.000000742 | 0.8596 |
| oxalic acid | – | – | – | – | 0.447497026130133 | 0.00000000193 | 0.0000000543 | 1.4044 |
| threitol | – | – | – | – | 4.05336192643834 | 0.000000000106 | 0.00000000358 | 1.3488 |
| paracetamol | – | – | – | – | 4.72964204582074 | 0.0000000000286 | 0.000000000121 | 1.2319 |
| adenosine-5-phosphate | – | – | – | – | 3.86407741984872 | 0.000000000022 | 0.00000000121 | 1.3045 |
| erythritol | – | V | – | – | 0.206079085276544 | 2.58e-17 | 0.00000000000000218 | 1.6743 |
| indole-3-acetate | – | – | – | – | 0.247020041160623 | 3.62e-18 | 6.12e-16 | 1.6853 |
| Metabolite | Comparative study | Author-emphasized biomarkers | Cutoff value | AUROC (95%CI) | Sensitivity (%) | Specificity (%) | Accuracy (%) |
|---|---|---|---|---|---|---|---|
| cystine | – | – | – | – | – | – | – |
| 3‐phosphoglycerate | – | – | – | – | – | – | – |
| dodecanol | – | – | – | – | – | – | – |
| caprylic acid | – | – | – | – | – | – | – |
| azelaic acid | – | – | – | – | – | – | – |
| urea | – | – | – | – | – | – | – |
| lyxose | – | – | – | – | – | – | – |
| maltose | – | – | – | – | – | – | – |
| kynurenine | – | – | – | – | – | – | – |
| naproxen | – | – | – | – | – | – | – |
| palmitoleic acid | – | – | – | – | – | – | – |
| salicylic acid | – | – | – | – | – | – | – |
| butane-2,3-diol | – | – | – | – | – | – | – |
| oleic acid | – | – | – | – | – | – | – |
| inosine | – | – | – | – | – | – | – |
| fructose | – | – | – | – | – | – | – |
| 2‐Hydroxyhippuric acid | – | – | – | – | – | – | – |
| oxalic acid | – | – | – | – | – | – | – |
| threitol | – | – | – | – | – | – | – |
| paracetamol | – | – | – | – | – | – | – |
| adenosine-5-phosphate | – | – | – | – | – | – | – |
| erythritol | – | V | – | (0.914, 1.000) | 93.1 | 100 | – |
| indole-3-acetate | – | – | – | – | – | – | – |
Paper graphical summary
