Metabolite page

Showing information for HMDB0000472 ('5-hydroxytryptophan')

Metabolite information
HMDB ID	HMDB0000472
Synonyms	(S)-5-Hydroxytryptophan 5 Hydroxytryptophan 5-HTP 5-Hydroxy- tryptophan 5-Hydroxy-L-tryptophan 5-Hydroxyl-L-tryptophan 5-Hydroxytryptophan 5-Hydroxytryptophan L-form Cincofarm Hydroxy-5 L-tryptophane Hydroxytryptophan L-5-HTP L-5-Hydroxytryptophan Levothym Levotonine Oxitriptan Oxyfan Oxytryptophan Pretonine Quietim Serotonyl Telesol Tript-OH Triptene Triptum Tryptophan, 5 hydroxy
Chemical formula	C11H12N2O3
IUPAC name	(2S)-2-amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid
CAS registry number	4350-09-8
Monoisotopic molecular weight	220.08479226
Chemical taxonomy
Super class	Organoheterocyclic compounds
Class	Indoles and derivatives
Sub class	Tryptamines and derivatives
Biological properties
Pathways (Pathway Details in HMDB)

The paper(s) that report HMDB0000472 as a lung cancer biomarker

The studies that identify HMDB0000472 as a lung cancer-related metabolite

Reference	Country	Specimen	Marker function	Participants (Case)						Participants (Control)
Reference	Country	Specimen	Marker function	Cancer type	Stage	Number	Gender (M,F)	Age mean (range) (M/F)	Smoking status	Type	Number	Gender (M,F)	Age mean (range) (M/F)	Smoking status
Wen et al. 2013	China	plasma	diagnosis	adenocarcinoma	I	31	15, 16	median: 63 (40-81)	smoker, non-smoker	healthy	28	20, 8	median: 37 (29-50)	smoker, non-smoker
Moreno et al. 2018	Spain	tissue	therapy, diagnosis	squamous cell carcinoma	I, II, III	35	35, 0	68.71 ± 7.46	–	tumor vs. adjacent normal tissue	35	35, 0	68.71 ± 7.46	–

Reference	Chromatography	Ion source	Positive/Negative mode	Mass analyzer	Identification level
Wen et al. 2013	GC	EI	–	–	–
Moreno et al. 2018	LC, GC	ESI, EI	both	LC: linear ion-trap, GC: single-quadrupole	LC: MS/MS

Reference	Data processing software	Database search
Wen et al. 2013	MassHunter, Mass Profiler Professional software (Agilent)	NIST 08, HMDB, METLIN, LIPID MAPS
Moreno et al. 2018	–	KEGG, HMDB

Differential analysis
Classification analysis

Reference	Difference method	Mean concentration (case)	Mean concentration (control)	Fold change (case/control)	P-value	FDR	VIP
Wen et al. 2013	Mann–Whitney–Wilcoxon test, OPLS-DA		–	0.37	7.72e-03	–	1.19
Moreno et al. 2018	paired two-sample t-test, PLS-DA	–	–	1.64	6.54e-05	1.22e-04	–

Reference	Classification method	Cutoff value	AUROC 95%CI	Sensitivity (%)	Specificity (%)	Accuracy (%)
Wen et al. 2013	ROC curve analysis	–	0.7	–	–	–
Moreno et al. 2018	–	–	–	–	–	–